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KMID : 1143420200130010069
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Public Health Weekly Report
2020 Volume.13 No. 1 p.69 ~ p.76
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Molecular epidemiology of Mycobacterium tuberculosis isolates from foreigners among the contact investigations in Korea, 2017-2018
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Ha Jee-Min
Yoo Jae-Il
Kim Dong-Hyeok
Hwang Kyu-Jam
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Abstract
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In South Korea, the number of local tuberculosis (TB) patients has continued to decline, whereas the proportion of foreign
TB patients has been on the rise. This epidemiology study aimed to explore the characteristics of genotypes and transmission routes of TB isolates in foreign patients. This study genotyped a total of 3,253 mycobacterium tuberculosis
isolates from congregate facilities, such as schools, companies, and hospitals etc., with conventional contact investigations from 2017 to 2018. TB genotyping was performed with using spoligotyping and 24-loci Mycobacterial Interspersed Repetitive Unit-Variable Number Tandem Repeat (MIRU-VNTR). TB isolates from foreign patients were 141 and 92.2% of isolates were belong to 14 countries with high TB incidence. The distribution of the lineage of TB strains from foreigners were different from regions and countries. And clustering rate of TB isolates from foreigners (23.4%) was lower than that of Korean (55.3%). In conclusion, reactivaton of latent TB infection seems to be a major risk factor for foregin active TB cases rather than recent transmission. The need to expand the analyzing group from contact investigatin setting to entire TB patients in Korea and employ the newer molecular technique such as whole genome sequence is advocated.
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KEYWORD
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Mycobacterium tubercuosis, Foreigner, molecular ty
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